South Western Sydney Clinical School

Po JW; Ma Y; Balakrishna B; Brungs D; Azimi F; De Souza P; Becker TM, 2019, 'Immunomagnetic isolation of circulating melanoma cells and detection of PD-L1 status', PLoS ONE, vol. 14, http://dx.doi.org/10.1371/journal.pone.0211866

Ding PN; Ma YF; Roberts TJ; Chua W; Bray VJ; Lynch D; Burke D; Souza PD; Becker TM, 2018, 'Droplet Digital PCR Based Detection of EGFR Mutations in Advanced Lung Cancer Patient Liquid Biopsies: A Comparison of Circulating Tumour DNA Extraction Kits', Journal of Molecular Biomarkers & Diagnosis, vol. 09, http://dx.doi.org/10.4172/2155-9929.1000397

Po JW; Roohullah A; Lynch D; DeFazio A; Harrison M; Harnett PR; Kennedy C; de Souza P; Becker TM, 2018, 'Improved ovarian cancer EMT-CTC isolation by immunomagnetic targeting of epithelial EpCAM and mesenchymal N-cadherin', Journal of Circulating Biomarkers, vol. 7, http://dx.doi.org/10.1177/1849454418782617

Brungs D; Lynch D; Luk AWS; Minaei E; Ranson M; Aghmesheh M; Vine KL; Carolan M; Jaber M; De Souza P, 2018, 'Cryopreservation for delayed circulating tumor cell isolation is a valid strategy for prognostic association of circulating tumor cells in gastroesophageal cancer', World Journal of Gastroenterology, vol. 24, pp. 810 - 818, http://dx.doi.org/10.3748/wjg.v24.i7.810

Ding PN; Roberts TL; Chua W; Becker TM; Descallar J; Yip PY; Bray V, 2017, 'Clinical outcomes in patients with advanced epidermal growth factor receptor-mutated non-small-cell lung cancer in South Western Sydney Local Health District', Internal Medicine Journal, vol. 47, pp. 1405 - 1411, http://dx.doi.org/10.1111/imj.13555

Pang TCY; Xu Z; Pothula S; Becker T; Goldstein D; Pirola RC; Wilson JS; Apte MV, 2017, 'Circulating pancreatic stellate (stromal) cells in pancreatic cancer-a fertile area for novel research', Carcinogenesis, vol. 38, pp. 588 - 591, http://dx.doi.org/10.1093/carcin/bgx030

Luk AWS; Ma Y; Ding PN; Young FP; Chua W; Balakrishnar B; Dransfield DT; De Souza P; Becker TM, 2017, 'CTC-mRNA (AR-V7) analysis from blood samples—impact of blood collection tube and storage time', International Journal of Molecular Sciences, vol. 18, http://dx.doi.org/10.3390/ijms18051047

Brungs D; Chen J; Aghmesheh M; Vine KL; Becker TM; Carolan MG; Ranson M, 2017, 'The urokinase plasminogen activation system in gastroesophageal cancer: A systematic review and meta-analysis', Oncotarget, vol. 8, pp. 23099 - 23109, http://dx.doi.org/10.18632/oncotarget.15485

Ma Y; Luk A; Young FP; Lynch D; Chua W; Balakrishnar B; de Souza P; Becker TM, 2016, 'Droplet digital PCR based androgen receptor variant 7 (AR-V7) detection from prostate cancer patient blood biopsies', International Journal of Molecular Sciences, vol. 17, http://dx.doi.org/10.3390/ijms17081264

Brungs D; Aghmesheh M; Vine KL; Becker TM; Carolan MG; Ranson M, 2016, 'Gastric cancer stem cells: evidence, potential markers, and clinical implications', Journal of Gastroenterology, http://dx.doi.org/10.1007/s00535-015-1125-5

Tognela A; Spring KJ; Becker T; Caixeiro NJ; Bray VJ; Yip PY; Chua W; Lim SH; de Souza P, 2015, 'Predictive and prognostic value of circulating tumor cell detection in lung cancer: A clinician's perspective', Critical Reviews in Oncology/Hematology, vol. 93, pp. 90 - 102, http://dx.doi.org/10.1016/j.critrevonc.2014.10.001

Todd JR; Scurr LL; Becker TM; Kefford RF; Rizos H, 2014, 'The MAPK pathway functions as a redundant survival signal that reinforces the PI3K cascade in c-Kit mutant melanoma.', Oncogene, vol. 33, pp. 236 - 245, http://dx.doi.org/10.1038/onc.2012.562

Becker TM; Boyd SC; Mijatov B; Gowrishankar K; Snoyman S; Pupo GM; Scolyer RA; Mann GJ; Kefford RF; Zhang XD, 2014, 'Mutant B-RAF-Mcl-1 survival signaling depends on the STAT3 transcription factor.', Oncogene, vol. 33, pp. 1158 - 1166, http://dx.doi.org/10.1038/onc.2013.45

Rizos H; Menzies AM; Pupo GM; Carlino MS; Fung C; Hyman J; Haydu LE; Mijatov B; Becker TM; Boyd SC, 2014, 'BRAF inhibitor resistance mechanisms in metastatic melanoma: spectrum and clinical impact.', Clin Cancer Res, vol. 20, pp. 1965 - 1977, http://dx.doi.org/10.1158/1078-0432.CCR-13-3122

Caixeiro NJ; Kienzle N; Lim SH; Spring KJ; Tognela A; Scott KF; De Souza P; Becker TM, 2014, 'Circulating tumour cells - A bona fide cause of metastatic cancer', Cancer and Metastasis Reviews, vol. 33, pp. 747 - 756, http://dx.doi.org/10.1007/s10555-014-9502-8

Lim SH-S; Becker TM; de Souza P; Spring KJ; Chua W; Ng WL, 2014, 'Circulating tumour cells and the epithelial mesenchymal transition in colorectal cancer', Journal of Clinical Pathology, http://dx.doi.org/10.1136/jclinpath-2014-202499

Caixeiro NJ; Kienzle N; Lim SH; Spring KJ; Tognela A; Scott KF; de Souza P; Becker TM, 2014, 'Circulating tumour cells-a bona fide cause of metastatic cancer', Cancer and Metastasis Reviews, http://dx.doi.org/10.1007/s10555-014-9502-8

Becker TM; Caixeiro NJ; Lim SH; Tognela A; Kienzle N; Scott KF; Spring KJ; De Souza P, 2014, 'New frontiers in circulating tumor cell analysis: A reference guide for biomolecular profiling toward translational clinical use', International Journal of Cancer, vol. 134, pp. 2523 - 2533, http://dx.doi.org/10.1002/ijc.28516

Lim SH; Becker TM; Caixeiro NJ; Kienzle N; Tognela A; Lumba S; De Souza P; Spring KJ; Chua W; Ng WL, 2014, 'Circulating tumour cells and circulating free nucleic acid as prognostic and predictive biomarkers in colorectal cancer', Cancer Letters, vol. 346, pp. 24 - 33, http://dx.doi.org/10.1016/j.canlet.2013.12.019

Haferkamp S; Borst A; Adam C; Becker TM; Motschenbacher S; Windhövel S; Hufnagel AL; Houben R; Meierjohann S, 2013, 'Vemurafenib induces senescence features in melanoma cells.', J Invest Dermatol, vol. 133, pp. 1601 - 1609, http://dx.doi.org/10.1038/jid.2013.6

Boyd SC; Mijatov B; Pupo GM; Tran SL; Gowrishankar K; Shaw HM; Goding CR; Scolyer RA; Mann GJ; Kefford RF, 2013, 'Oncogenic B-RAF(V600E) signaling induces the T-Box3 transcriptional repressor to repress E-cadherin and enhance melanoma cell invasion.', J Invest Dermatol, vol. 133, pp. 1269 - 1277, http://dx.doi.org/10.1038/jid.2012.421

Todd JR; Becker TM; Kefford RF; Rizos H, 2013, 'Secondary c-Kit mutations confer acquired resistance to RTK inhibitors in c-Kit mutant melanoma cells.', Pigment Cell Melanoma Res, vol. 26, pp. 518 - 526, http://dx.doi.org/10.1111/pcmr.12107

Carlino MS; Gowrishankar K; Saunders CAB; Pupo GM; Snoyman S; Zhang XD; Saw R; Becker TM; Kefford RF; Long GV, 2013, 'Antiproliferative effects of continued mitogen-activated protein kinase pathway inhibition following acquired resistance to BRAF and/or MEK inhibition in melanoma.', Mol Cancer Ther, vol. 12, pp. 1332 - 1342, http://dx.doi.org/10.1158/1535-7163.MCT-13-0011

Becker TM, 2012, 'Chromatin Remodeling in Carcinoma Cells', Reviews in Cell Biology and Molecular Medicine, http://dx.doi.org/10.1002/3527600906.mcb.201100031

Gowrishankar K; Snoyman S; Pupo GM; Becker TM; Kefford RF; Rizos H, 2012, 'Acquired resistance to BRAF inhibition can confer cross-resistance to combined BRAF/MEK inhibition.', J Invest Dermatol, vol. 132, pp. 1850 - 1859, http://dx.doi.org/10.1038/jid.2012.63

Tran SL; Haferkamp S; Scurr LL; Gowrishankar K; Becker TM; Desilva C; Thompson JF; Scolyer RA; Kefford RF; Rizos H, 2012, 'Absence of distinguishing senescence traits in human melanocytic nevi.', J Invest Dermatol, vol. 132, pp. 2226 - 2234, http://dx.doi.org/10.1038/jid.2012.126

Scurr LL; McKenzie HA; Becker TM; Irvine M; Lai K; Mann GJ; Scolyer RA; Kefford RF; Rizos H, 2011, 'Selective loss of wild-type p16(INK4a) expression in human nevi.', J Invest Dermatol, vol. 131, pp. 2329 - 2332, http://dx.doi.org/10.1038/jid.2011.197

Irvine M; Philipsz S; Frausto M; Mijatov B; Gallagher SJ; Fung C; Becker TM; Kefford RF; Rizos H, 2010, 'Amino terminal hydrophobic import signals target the p14(ARF) tumor suppressor to the mitochondria.', Cell Cycle, vol. 9, pp. 829 - 839, http://dx.doi.org/10.4161/cc.9.4.10785

Scurr LL; Pupo GM; Becker TM; Lai K; Schrama D; Haferkamp S; Irvine M; Scolyer RA; Mann GJ; Becker JC, 2010, 'IGFBP7 is not required for B-RAF-induced melanocyte senescence.', Cell, vol. 141, pp. 717 - 727, http://dx.doi.org/10.1016/j.cell.2010.04.021

McKenzie HA; Fung C; Becker TM; Irvine M; Mann GJ; Kefford RF; Rizos H, 2010, 'Predicting functional significance of cancer-associated p16(INK4a) mutations in CDKN2A.', Hum Mutat, vol. 31, pp. 692 - 701, http://dx.doi.org/10.1002/humu.21245

Becker TM; Philipsz S; Scurr LL; Fung C; Haferkamp S; Kefford RF; Rizos H, 2010, 'Oncogenic B-RAF(V600E) promotes anchorage-independent survival of human melanocytes.', J Invest Dermatol, vol. 130, pp. 2144 - 2147, http://dx.doi.org/10.1038/jid.2010.117

Jiang CC; Lai F; Tay KH; Croft A; Rizos H; Becker TM; Yang F; Liu H; Thorne RF; Hersey P, 2010, 'Apoptosis of human melanoma cells induced by inhibition of B-RAFV600E involves preferential splicing of bimS.', Cell Death Dis, vol. 1, pp. e69, http://dx.doi.org/10.1038/cddis.2010.48

Becker TM; Haferkamp S; Dijkstra MK; Scurr LL; Frausto M; Diefenbach E; Scolyer RA; Reisman DN; Mann GJ; Kefford RF, 2009, 'The chromatin remodelling factor BRG1 is a novel binding partner of the tumor suppressor p16INK4a.', Mol Cancer, vol. 8, pp. 4, http://dx.doi.org/10.1186/1476-4598-8-4

McKenzie H; Becker TM; Scurr LL; Kefford RF; Rizos H, 2009, 'Wild type and melanoma-associated mutant p16(IN4a) proteins do not oligomerize in vivo.', Pigment Cell Melanoma Res, vol. 22, pp. 131 - 133, http://dx.doi.org/10.1111/j.1755-148X.2008.00530.x

Haferkamp S; Tran SL; Becker TM; Scurr LL; Kefford RF; Rizos H, 2009, 'The relative contributions of the p53 and pRb pathways in oncogene-induced melanocyte senescence.', Aging (Albany NY), vol. 1, pp. 542 - 556, http://dx.doi.org/10.18632/aging.100051

Haferkamp S; Scurr LL; Becker TM; Frausto M; Kefford RF; Rizos H, 2009, 'Oncogene-induced senescence does not require the p16(INK4a) or p14ARF melanoma tumor suppressors.', J Invest Dermatol, vol. 129, pp. 1983 - 1991, http://dx.doi.org/10.1038/jid.2009.5

Haferkamp S; Becker TM; Scurr LL; Kefford RF; Rizos H, 2008, 'p16INK4a-induced senescence is disabled by melanoma-associated mutations.', Aging Cell, vol. 7, pp. 733 - 745, http://dx.doi.org/10.1111/j.1474-9726.2008.00422.x

Rizos H; McKenzie HA; Ayub AL; Woodruff S; Becker TM; Scurr LL; Stahl J; Kefford RF, 2006, 'Physical and functional interaction of the p14ARF tumor suppressor with ribosomes.', J Biol Chem, vol. 281, pp. 38080 - 38088, http://dx.doi.org/10.1074/jbc.M609405200

Becker TM; Rizos H; de la Pena A; Leclercq IA; Woodruff S; Kefford RF; Mann GJ, 2005, 'Impaired inhibition of NF-kappaB activity by melanoma-associated p16INK4a mutations.', Biochem Biophys Res Commun, vol. 332, pp. 873 - 879, http://dx.doi.org/10.1016/j.bbrc.2005.05.032

Becker TM; Ayub AL; Kefford RF; Mann GJ; Rizos H, 2005, 'The melanoma-associated 24 base pair duplication in p16INK4a is functionally impaired.', Int J Cancer, vol. 117, pp. 569 - 573, http://dx.doi.org/10.1002/ijc.21265

Fung DCY; Holland EA; Becker TM; Hayward NK; Bressac-de Paillerets B; Mann GJ; Melanoma Genetics Consortium, 2003, 'eMelanoBase: an online locus-specific variant database for familial melanoma.', Hum Mutat, vol. 21, pp. 2 - 7, http://dx.doi.org/10.1002/humu.10149

Rizos H; Diefenbach E; Badhwar P; Woodruff S; Becker TM; Rooney RJ; Kefford RF, 2003, 'Association of p14ARF with the p120E4F transcriptional repressor enhances cell cycle inhibition.', J Biol Chem, vol. 278, pp. 4981 - 4989, http://dx.doi.org/10.1074/jbc.M210978200

Becker TM; Rizos H; Kefford RF; Mann GJ, 2001, 'Functional impairment of melanoma-associated p16(INK4a) mutants in melanoma cells despite retention of cyclin-dependent kinase 4 binding.', Clin Cancer Res, vol. 7, pp. 3282 - 3288, https://www.ncbi.nlm.nih.gov/pubmed/11595726

Rizos H; Becker TM; Holland EA; Kefford RF; Mann GJ, 1997, 'Differential expression of p16INK4a and p16beta transcripts in B-lymphoblastoid cells from members of hereditary melanoma families without CDKN2A exon mutations.', Oncogene, vol. 15, pp. 515 - 523, http://dx.doi.org/10.1038/sj.onc.1201217

Holland EA; Beaton SC; Becker TM; Grulet OM; Peters BA; Rizos H; Kefford RF; Mann GJ, 1995, 'Analysis of the p16 gene, CDKN2, in 17 Australian melanoma kindreds.', Oncogene, vol. 11, pp. 2289 - 2294, https://www.ncbi.nlm.nih.gov/pubmed/8570179