Researchers within the Department of Respiratory Medicine at Liverpool Hospital are working on a wide-range of problems in respiratory and sleep medicine and science including asthma, COPD, sleep disorders and tuberculosis. Research on tuberculosis has examined the outcomes of treatment for tuberculosis in NSW, the risk for tuberculosis among people with diabetes and with renal failure in Australia and the effectiveness of contact tracing in people exposed to patients with tuberculosis in south-western and western Sydney.
The Childhood Asthma Prevention Study, a long-term clinical trial of preventive interventions for asthma implemented in a high-risk birth cohort, continues as a cohort study and is now investigating changes in respiratory, allergic and cardiovascular characteristics during puberty.
A number of clinical trials are underway including investigations of new treatments to prevent exacerbations of chronic obstructive pulmonary disease, for severe asthma and for bronchiectasis. Clinical research also includes a randomised study of reslizumab in eosinophilic asthma, an open label study of reslizumab in asthma, a randomised study of macrolide therapy in asthma; a multicentre trial utilising a pulmonary hypertension patient registry; and prophylactic treatment of latent (dormant) tuberculosis infection in New South Wales.
Researchers within the Department are also leading the development of the Australasian Severe Asthma Network and are developing a new research collaboration with the Mongolian National Tuberculosis Program to determine the effectiveness of community-based tuberculosis treatment programs in Mongolia. The Department is also active in supervising Independent Learning Project students who have focussed their work on health care workers' experiences with tuberculosis screening services and the epidemiology of lymph node tuberculosis in south-western Sydney.
In sleep medicine, researchers are engaged in studies on new approaches to early diagnosis of obstructive sleep apnoea. Researchers will also be examining methods for early detection of mesothelioma.